NCI Well Connect Mid-Week Brief
October 5, 2016
Dear Steve, 

DID YOU KNOW that use of hormonal contraception, especially among adolescents, was associated with subsequent use of antidepressants and a first diagnosis of depression? The study, from the September issue of JAMA Psychiatry, alludes to depression as a potential adverse effect of hormonal contraceptive use.

Redeem Your Loyalty Rewards by December 31, 2016
Our loyalty program provides discounts when product purchase benchmarks are met. Your rewards zero out every January 1. So get your orders in!

Have a happy, healthy day. Steve and Bonnie
 
Medication and Supplement Safety Update
Bonnie and Steve: At least four times per year, we try to update you on warnings/recalls concerning medication, supplements, and/or medical procedures. Our last update was in May.

ADHD Stimulant Medication
In a study from this week's JAMA Pediatrics, children and adolescents reporting stimulant use had lower DXA measurements of the lumbar spine and femur compared with nonusers. The findings support the need to further examine the effects of stimulant use on bone mass in children.

Antibiotics
The FDA updated warnings for fluoroquinolone antibiotics. They now suggest fluoroquinolones as the "last resort" for acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis and uncomplicated urinary tract infections because of the serious side effects.

Anxiety Med
The widely prescribed drug pregabalin (Lyrica) may slightly increase the risk for birth defects, according to a study in the May issue of Neurology. Researchers found that among women taking Lyrica during the first trimester of pregnancy, 6 percent had infants with major birth defects as opposed to 2 percent of women who weren't taking the drug.

Dry Eye 
The FDA has approved lifitegrast ophthalmic solution (Xiidra, Shire) for the treatment of signs and symptoms of dry eye disease. We only recommend trying this if no other alternatives have worked. Otherwise, wait three years to see how it is tolerated.

Homeopathic Teething Tablets, Gels
The FDA issued a statement on September 30th, recommending that consumers discontinue use of homeopathic teething tablets and gels because they may pose a risk because of the ingredient belladonna. The amount of Belladonna used in Hyland's Baby Teething Tablets, for example, is miniscule. There's two trillionths of a milligram in a tablet. A child would have to eat multiple bottles at once to experience the first side effect of belladonna, which is typically dry mouth.

Medical Treatments
The adverse effects (AEs) of medical treatments appear to be underreported in peer-reviewed journal articles documenting the results of clinical trials, according to a new study in PLoS Medicine.

There is strong evidence that much of the information on adverse events remains unpublished and that the number and range of adverse events is higher in unpublished than in published versions of the same study.

The extent of 'hidden' or 'missing' data prevents researchers, clinicians, and patients from gaining a full understanding of harm, and this may lead to incomplete or erroneous judgements on the perceived benefit to harm profile of an intervention.

The authors note that serious concerns have emerged about publication bias and outcome reporting bias in clinical trials, which can lead to overestimation of treatment benefits and underreporting of negative results.

Specifically, if readers had relied only on published documents to evaluate clinical trials' data, they would have missed 43% to 100% (median, 64%) of AEs associated with medical treatments, including 2% to 100% of serious AEs.

"Our findings suggest that it will not be possible to develop a complete understanding of the harms of an intervention unless urgent steps are taken to facilitate access to unpublished data," the authors concluded.

Oral Hormonal Contraceptives
Use of hormonal contraception, especially among adolescents, was associated with subsequent use of antidepressants and a first diagnosis of depression. The study from the September issue of JAMA Psychiatry alludes to depression as a potential adverse effect of hormonal contraceptive use.

Osteoporosis Meds
Gastrointestinal side effects, not osteonecrosis of the jaw or atypical femur fractures, are the most common reason osteoporotic women cite for nonadherence to oral bisphosphonate therapy, according to a new study from Advances in Therapy.

Statins
In a group of older adults hospitalized with Coronary Artery Disease, statin therapy had no significant effect on long-term survival. The findings, published in the August issue of Journal of the American Geriatrics Society, call into question the benefit of statin therapy in adults aged 80 and older.
 
Special Green Split Pea Soup Recipe
This article is reserved for NCI Well Connect Members.
 
Future of Genetics & Wellness Is Now
Bonnie and Steve: It only takes a few simple steps to get individualized genetic nutritional support. Test your genome. We translate the results in a way you can understand. We target your individualized needs with nutritional support that can be easily implemented.

 
NCI Well Connect Membership
One Year Membership Includes:
  1. Weekly eNewsletters (84 issues). We publish our long-form issue on Monday and a Mid-Week Brief on Wednesday. Recent preview issue here.
  2. Self-Help Action Plans. Access to two titles per month from our self-help Action Plan Library. There are currently 42 Action Plan titles to date on all aspects of wellness, including the new Eye-Mazing Vision Protection Action Plan. You can view the full library of titles here.
  3. Natural Foods Shopping List. Updated quarterly, our Natural Foods Shopping List includes only the most meticulously vetted, highest quality food and beverage products that we recommend to our clients. These include gluten-free, corn-free, and kosher pareve items.
  4. 30 Minutes Free Pure Genomics Analysis & Coaching (Bonnie's services are separate).
The approximate cost for all of this? Less than one dollar a week!
We appreciate your continued patronage and support.

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Have a happy, healthy day,
 
Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Jeannie
(847) 498 3422 
support@nutritionalconcepts.com 
http://www.nutritionalconcepts.com

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