NCI Well Connect
April 23, 2018
Dear Steve, 

DID YOU KNOW that even the pancreas has a microbiome, one that influences pancreatic cancer progression and that can be manipulated to resensitize the immune response in pancreatic adenocarcinoma?

A new study in the March issue of Cancer Discovery shows that pancreatic cancer harbors a 1000-fold higher concentration of bacteria compared with the normal pancreas. Moreover, the bacterial species in the pancreatic microbiome can shut down the immune response so that the pancreatic carcinoma milieu becomes ruled by immune suppression.

In animal models, when the microbiome is ablated, the immune response is restored, and the animals are able to respond to immunotherapy. Hence, genetic mutations are not the sole components that explain pancreatic cancer progression. This is a huge discovery for such a fatal type of cancer.

Have a happy, healthy day! Steve and Bonnie
NCI Well Connect Highlights
Steve Minsky
From Editor Steve Minsky
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Read stories like these twice weekly from our eNewsletter, access two titles per month from our Action Plan Library, and get one free wellness coaching session with an NCI Well Connect Membership Here Today!
A Probiotic Primer

Bonnie and Steve: Last week, we wrote a piece on why we need long-term probiotic supplementation. We would like to expand on that.

Please indulge us while we gently "reintroduce" to you probiotics, including which strains are beneficial for specific maladies.

When Bonnie first began taking probiotics 40 years ago, the medical community said they were dangerous. She was not deterred, however, because Dr. Khem Shahani had done incredible research at the University of Nebraska regarding the DDS Lactobacillus Acidophilus strain, one of the first probiotics. Dr. Shahani roamed the world treating serious digestive problems with his probiotic strain. 

When Bonnie began recommending his formulation of probiotics to clients, we saw major improvements in their digestive symptoms and overall health. We still recommend his strain to this day. Most gastroenterologists even recommend probiotics to their patients, although many of the formulations are awful.

The term, "probiotics", means good bacteria. They are friendly microbes that live in our digestive tracts. They can be taken as supplements, but are also found naturally in fermented foods such as sauerkraut, kimchi, yogurt, kefir, and miso.  Bonnie's maternal grandmother, who lived to the healthy age of 103, credits regular ingestion of sauerkraut as her key to good health!

Gut microflora get their nutrients from our bodies and create a healthy environment that protects us from illness, helps in disease control, and aids in digestion of our food. Beneficial gut flora facilitate health by producing several B vitamins (especially B-12), vitamin K, and certain fatty acids. The byproducts of healthy bacterial action supply up to 10% of our body's daily energy needs. We have now learned that pregnant women who take probiotics find faster development of the fetal immune and digestive systems. Many baby foods now have even added probiotics because of the benefits to an infant's system.

Extensive research is continuing to show the important relationship between probiotics and many aspects of overall health, including mental health, prevention of obesity, gluten digestion (if not celiac), lactose digestion, prevention of inflammatory bowel disease, autoimmune disorders, and even atherosclerosis. The numbers and balance of these bacteria are affected by diet, medications, aging, infections, pathogenic invasions, and most importantly, overuse of antibiotics. Over-prescriptions of antibiotics by physicians, but especially antibiotic residues found in many animal foods, have weakened or totally destroyed our bodies' probiotic bacteria. Disruption and destruction of probiotic balance has led to significant health problems, including fungal/yeast overgrowth and weakening of our digestive systems.   

Probiotics are vital for the immune system. They actually send signals to the immune system that reduce destructive overreactions, especially inflammation.  Insufficient probiotic gut flora affect our immune responses so greatly that every aspect of our health can be compromised.

After studying probiotics extensively, just as different antibiotics are used to treat different types infections, the same probiotics cannot be used for every person or specific health issue. Probiotic manufacturers often tout their products as the best because they have billions of organisms and have multiple strains. However, if there are too many strains and organisms, or if they have not been manufactured properly, the probiotics may be counterproductive or useless.

Additionally, it is also important that an individual chooses a probiotic that is free of any known food reactor ingredient (such as corn, dairy, and even rice for some). 

There's a delicate balance between good and bad microflora in the gut. It is much likelier that good bacteria lose out to bad. We need to keep replenishing the good. It keeps yeast in check. If we eat contaminated food or illness-causing pathogens, our good microflora can prevent or greatly reduce reactions.

So the big question is...who should take probiotics regularly? Everyone of course, but because we are not one-size-fits-all, probiotics need to be individualized.

In order to access the best probiotic options, whether for maintenance use or for specific health conditions, the following can be accessed by paid members of NCI Well Connect. Get a membership here and we will send you today's full issue with recommendations.
Genetic Wellness Screening
Pure Genomics, our genetic wellness screening, covers 32 impeccably well-researched genes in seven categories:
  1. Methylation
  2. Vitamins and Minerals
  3. Detoxification
  4. Weight Management
  5. Cognitive Health and Memory
  6. Blood Sugar Balance
  7. Immune Health
Pure Genomics tips the balance toward optimal wellness. It only takes four simple steps to get started:
  1. Order a genetic kit from or
  2. Send your saliva sample back to 23andMe or Ancestry. They will email you when your results are ready.
  3. Download your raw genetic data file to your computer. Email us the data file.
  4. We generate your Pure Genomics report and contact you with the next step.
Email Steve for further questions or clarification.
Video: Smart Takeout
Action Plan of the Month:
Healthy Bones
One of the benefits of being a NCI Well Connect Member is that you can request two titles monthly from our our Action Plan Library (43 plans: total value $300). 

This comes in handy when you're interested in getting information about how to keep your bones healthy. Our Healthy Bones Action Plan is the most complete self-help guide you will find anywhere! 

Action Plans are free by email request for NCI Well Connect Members or can be ordered separately. To activate your NCI Well Connect Membership this month, click here.
eNews Briefs
NCI Well Connect Member Benefits

One Year Membership Is Open to Clients and Non-Clients of our practice. Includes:
  1. Free 45 Minute Pure Genomics Screening & Consultation
  2. Twice Weekly eNewsletters. Long-form issue on Monday and mid-week brief on Wednesday.
  3. Self-Help Action Plans. Access to two titles per month from our 43 title self-help Action Plan Library. Full library of titles here.
  4. Natural Foods Shopping List. Meticulously vetted, high quality food and beverages we recommend to our clients. Gluten-free, corn-free, and kosher pareve items included. Updated quarterly.
Care's Corner Video
Food Intolerance: the Silent Assassin
Food Intolerance: the Silent Assassin
Be Your Own Medical Advocate
Aspirin-Like Substances in My Food
Salicylates in My Food? What Are Those?
We appreciate your patronage and support.

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Have a happy, healthy day,
Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Lori (not pictured)
(847) 498-3422  

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