NCI Well Connect
May 21, 2018
Dear Steve, 

Many of you have asked recently about our NCI Well Connect Membership. One of the numerous perks are the long-form eNewsletters that include numerous categories, covering all aspects of wellness.

Today, we are providing you with a free preview of our paid member issue. You'll notice that today's newsletter is longer and more informative than what you are used to. If you like what you see, we are offering a one year NCI Well Connect Membership at 25% OFF today at this link!

For details about what comes with an NCI Well Connect Membership, see below.

DID YOU KNOW that your suntan lotion may contain nanoparticles? Many suntan lotions that contain zinc oxide or titanium dioxide are using nano-forms of these minerals. Because of this, many brands are labeling their lotions as "Nano-free". Why is this important?

A new study from Nature Nanotechnology found that when cellular barriers are exposed to any type of metal nanoparticles, cellular messengers are released that may cause damage to the DNA of developing brain cells, or any cell for that matter.

Nanoparticles are very small particles of between 1-100 nanometers in size. They are being increasingly used in cosmetics, food, drug delivery, chemotherapy, imaging and diagnostics due to their ability to travel within organisms by utilizing cellular pathways.

Have a happy, healthy day! Steve and Bonnie
NCI Well Connect Highlights
Steve Minsky
From Editor Steve Minsky
Click the links below to be taken directly to each story. This may not work for all email services.
Read stories like these twice weekly from our eNewsletter, access two titles per month from our Action Plan Library, and get one free wellness coaching session with an NCI Well Connect Membership at 25% Off Here Today!
Well Connect Feature
Cannabis as Therapy for Anxiety, Depression, or Stress
Steve: In a first-of-a-kind study, scientists in in the Journal of Affective Disordersexamined how peoples' self-reported levels of stress, anxiety and depression were affected by smoking different strains and quantities of medical-grade cannabis at home.

Their results suggest smoking cannabis can significantly reduce short-term levels of depression, anxiety, and stress but may contribute to worse overall feelings of depression over time.

It marks one of the first attempts by U.S. scientists to assess how cannabis with varying concentrations of the chemical compounds tetrahydrocannabinol (THC) and cannabidiol (CBD) affect medicinal cannabis users' feelings of wellbeing when smoked outside of a laboratory.

For example, the research team found that one puff of cannabis high in CBD and low in THC was optimal for reducing symptoms of depression, two puffs of any type of cannabis was sufficient to reduce symptoms of anxiety, while 10 or more puffs of cannabis high in CBD and high in THC produced the largest reductions in stress.

The authors mention that a lot of consumers seem to be under the false assumption that more THC is always better. This study shows that CBD is also a very important ingredient in cannabis and may augment some of the positive effects of THC.

The researchers also found that while both sexes reported decreases in all three symptoms after using cannabis, women reported a significantly greater reduction in anxiety following cannabis use.

Part two next week!
Long Held Nutrition Beliefs in Peril
Bonnie and Steve: While on paper, all calories are created equal. The vast majority of health experts adhere to this law, but it is one we have vehemently fought against.

The body breaks down a calorie differently depending on its composition. For example, it takes less energy to break down a sugar calorie than a protein calorie. Thus, for a sedentary lifestyle, it is advantageous to consume protein calories with every meal, where you can spend more energy and induce satiety. 

In addition, calories affect our body in vastly different ways. For example, a calorie from trans fat has a more adverse effect on our body than a calorie from olive oil.

The latest study from Obesity Reviews echoes our belief that all calories are not created equal. For example, 22 nutrition researchers now admit that disease risk increases even when sugar sweetened beverages are consumed within diets that do not result in weight gain. As crazy as it may sound, many in the nutrition world did not believe this until recently.

So don't let anyone tell you that you're good as long as you expend as much fuel as you bring in. It is simply not true!

One Size Does Not Fit All
This has been the mission of our practice from the beginning. Yet, we have had to fight tooth and nail to convince our clients of this.

In the case of diabetes, at least, it seems the medical community may be getting the message. In the latest issue of Diabetic Medicine, new guidelines for maintaining optimal weight, glycemic control, and CVD prevention demand an "individualized approach". Key individualized recommendations beyond diet extend to physical activity, mental activity, and surgical and medical strategies.

We know it sounds crazy to think that for the longest time, we have not been treated as individuals, but this is one of the biggest reasons why much of the world's population is so ill.

Thankfully, because the genetic component is finally here, the medical world cannot ignore the uniqueness of each and every one of us.
Smart Food
Cancer Cell Suppressors?
Steve: Naturally occurring pigments in berries, also known as anthocyanins, increase the function of the sirtuin 6 enzyme in cancer cells, a new study from Scientific Reportsshows. The regulation of this enzyme could open up new avenues for cancer treatment.

Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signaling pathways. Aging causes changes in sirtuin function, and these changes contribute to the development of various diseases. Sirtuin 6, or SIRT6 for short, is a less well-known enzyme that is also linked to glucose metabolism.

Berries get their red, blue or purple color from natural pigments, anthocyanins. Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and also reduced the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumor suppressor FoXO3 gene in cells.

Hence, berry pigments negatively affect cancer cell activity.
Steve's Studies
Two New Inflammatory Genes on the Scene
Steve: There are two new genes in our Pure Genomics wellness screening that are extremely important for mitigating inflammation. We know because the research continues to tell us.

Metabolic syndrome (MetS) is a cluster of interrelated risk factors for type 2 diabetes mellitus, and cardiovascular disease, with underlying inflammatory pathophysiology. Genetic variations and diet are well-known risk factors for MetS, but the interaction between these two factors is less explored.

The aim of a new Clinical Nutrition study was to evaluate the influence of interaction between mutations of the IL-6 inflammatory gene and plasma fatty acids on the odds of MetS.

Not surprisingly, negatively expressed IL-6 gene mutations adversely affected plasma fatty acid profiles and showed an increased risk in MetS in subjects.

What is one way to bring the plasma fatty acid profiles into range, and thus, mitigate MetS? Supplement with EPA/DHA-rich fish oil.

TNF-Alpha, or tumor necrosis factor, is also a gene linked to inflammation. In the case of a recent JAMA Neurology study, mutations of TNF-Alpha were found to be associated with an increased risk of Inflammatory Bowel Disease (IBD) in subjects, which only compounded an increase for the risk of Parkinson's disease.

In these patients, anti-tumor necrosis factor therapy was successful in mitigating TNF-Alpha's negative expression. Thus, anyone who has mutations of this gene and have these chronic diseases would benefit from this therapy.

Fish oil is also recommend for TNF-Alpha mutations.
Bone Myth Debunked
Steve: A new expert consensus endorsed by the European Society for Clinical and Economical Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases and the International Osteoporosis Foundation has reviewed the benefits and safety of dietary protein for bone health.

The review, published in Osteoporosis International, found that a protein-rich diet, provided there is adequate calcium intake, is in fact beneficial for adult bone health. It also found no evidence that acid load due to higher dietary protein intakes, whether of animal or vegetable origin, is damaging to bone health.

The key findings of the extensive literature review include:
  • Hip fracture risk is modestly decreased with higher dietary protein intakes, provided calcium intakes are adequate;
  • Bone mineral density, which is an important determinant of bone strength, appears to be positively associated with dietary protein intakes;
  • Protein and calcium combined in dairy products have beneficial effects on calciotropic hormones, bone turnover markers and BMD. The benefit of dietary proteins on bone outcomes seems to require adequate calcium intakes;
  • There appears to be no direct evidence of osteoporosis progression, fragility fractures or altered bone strength with the acid load originating from a balanced diet.
Note that for decades, the medical community said the exact opposite, harming countless patients in the process.

This new consensus is vindicating for us, as we have always recommended that clients consume optimal protein for bone health.
Brand Buzz
Lack of Sleep and Your Taste Buds
Steve: According to a study in next month's Appetite, among the detrimental effects of sleep deprivation, a new one has emerged. Researchers have found that lack of sleep induces cravings by modifying our taste buds.

Not surprisingly, lack of sleep brings about more cravings by inducing greater satisfaction from sweet, fat, and umami tastes, while making sour and bitter tastes buds stronger, but in a negative way.

I bet many of you who have been sleep deprived at times can attest to these heightened sensations!
Green Lifestyle
Organic Versus Conventional Beef Production
Bonnie: It is well known that beef production typically has the greatest environmental impacts among various livestock production systems. 

Conventional beef production uses a large amount concentrate feed, which results in substantial environmental impacts, not to mention the methane and hydrogen sulfide emitted from cows in the form of gas from eating feed that is not compatible for their needs.

A Japanese study in Journal of Cleaner Production, comparing conventional farms to grass-fed organic farms, discovered that organic management, as well as feeding cows grass, mitigated all environmental impacts that conventional farming poses.
Genetic Wellness Screening
Pure Genomics, our genetic wellness screening, covers 32 impeccably well-researched genes in seven categories:
  1. Methylation
  2. Vitamins and Minerals
  3. Detoxification
  4. Weight Management
  5. Cognitive Health and Memory
  6. Blood Sugar Balance
  7. Immune Health
Pure Genomics tips the balance toward optimal wellness. It only takes four simple steps to get started:
  1. Order a genetic kit from or
  2. Send your saliva sample back to 23andMe or Ancestry. They will email you when your results are ready.
  3. Download your raw genetic data file to your computer. Email us the data file.
  4. We generate your Pure Genomics report and contact you with the next step.
Email Steve for further questions or clarification.
Video: Mindfulness Meditation Music
Wild Card
Be Choosy With Mouthwash
Steve: Over-the-counter mouthwash comprises part of routine oral care for many. However, potential adverse effects of the long-term daily use have not been evaluated, until now.

According to a new study in the journal Nitric Oxide, mouthwash use more than twice daily increases pre-diabetes/diabetes risk over three years. The association is independent of other major diabetes risk factors.

Researchers believe this may be due to antibacterial chemicals, which could impact oral microbes critical for nitric oxide formation, and in turn predispose to metabolic disorders, including diabetes.

As we just shown last week, nitric oxide is important for many health functions, including preventing depression and high blood pressure.

Our suggestion? Try to use mouthwash that contains xylitol as its antibacterial source.
"We judge ourselves by what we feel capable of doing, while others judge us by what we have already done."
-Henry Wadsworth
Action Plan of the Month:
Pain Relief Diet
One of the benefits of being a NCI Well Connect Member is that you can request two titles monthly from our our Action Plan Library (43 plans: total value $300). 

This comes in handy when you're trying to minimize pain and are not sure if certain foods are triggering it. Our Pain Relief Diet Action Plan is the most complete self-help guide you will find anywhere! 

Action Plans are free by email request for NCI Well Connect Members or can be ordered separately. To activate your NCI Well Connect Membership this month, click here.
eNews Briefs
NCI Well Connect Member Benefits

One Year Membership Is Open to Clients and Non-Clients of our practice. Includes:
  1. Free 45 Minute Pure Genomics Screening & Consultation
  2. Twice Weekly eNewsletters. Long-form issue on Monday and mid-week brief on Wednesday.
  3. Self-Help Action Plans. Access to two titles per month from our 43 title self-help Action Plan Library. Full library of titles here.
  4. Natural Foods Shopping List. Meticulously vetted, high quality food and beverages we recommend to our clients. Gluten-free, corn-free, and kosher pareve items included. Updated quarterly.
Care's Corner Video
Food Intolerance: the Silent Assassin
Food Intolerance: the Silent Assassin
Be Your Own Medical Advocate
Aspirin-Like Substances in My Food
Salicylates in My Food? What Are Those?
We appreciate your patronage and support.

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Have a happy, healthy day,
Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Lori (not pictured)
(847) 498-3422  

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