NCI Well Connect Mid-Week Brief
May 2, 2018
Dear Steve, 

DID YOU KNOW that one of the most well-known genes linked to an increased risk of cancer (breast and/or ovarian in women, prostate in men) is the BRCA gene?

This discovery, however, has been unable to explain why 60% of families with multiple breast cancer cases occur. Researchers in Nature Communications have found epigenetics (the impact of our environment on our genes) fill in a lot of the blanks with "epimutations" being passed through generations.

The changes in the way DNA works through these mutations was found to mimic cancers that develop in women carrying the BRCA1 gene. Researchers describe the findings as a "paradigm shifting for current clinical genetic testing and it explains an additional proportion of the currently unexplained multiple-case breast cancer families". Here's the piece.

Functional and lifestyle medicine practitioners like ourselves have long known that our health is dependent on the complex and continuous interactions between our genes, lifestyle choices and environmental influences. It's all about harmonizing positive epigenetic messages!

Pure Genomics can now process results from raw genetic data through In the past, we could only process 23andMe raw data. For those of who have done but did not want to spend the money for 23andMe, it is your lucky day!

the FDA just approved 23andMe screening for BRCA1 and BRCA2 genes, commonly associated with breast and ovarian cancer? We applaud the fact that access to this information is available at a much more reasonable price. For those who have no interest in learning of your genetic risk to these genes, simply do not opt-in and you will not have to see them in your 23andMe profile.

Have a happy, healthy day! Steve and Bonnie
Easy Way to Help Prevent Diabetes Risk
Bonnie and Steve: A study conducted by researchers in the April issue of PLOS Onesuggests that persons deficient in vitamin D may be at much greater risk of developing diabetes.

The scientists followed healthy adults with no indications of either pre-diabetes or diabetes during clinic visits from 1997 to 1999, and then followed the participants through 2009. Vitamin D levels in blood were measured during these visits, along with fasting plasma glucose and oral glucose tolerance.

For the study, the researchers identified the minimum healthy level of 25-hydroxyvitamin D in blood plasma to be 30 nanograms per milliliter. This is 10 ng/ml above the level recommended in 2010 by the Institute of Medicine, now part of The National Academies, a health advisory group to the federal government. Many groups, including ourselves, have argued for higher blood serum levels of vitamin D, as much as 50 ng/ml.

Participants with blood levels of 25-hydroxyvitamin D that were above 30 ng/ml had one-third of the risk of diabetes and those with levels above 50 ng/ml had one-fifth of the risk of developing diabetes.

So while levels above 30 are better, levels above 50 ng/ml are optimal.

According to the researchers, from a deficiency to reach 25-hydroxyvitamin D levels of 30 ng/ml, it would require dietary supplements of 3,000 to 5,000 international units (IU) per day, less with the addition of moderate daily sun exposure with minimal clothing (approximately 10-15 minutes per day outdoors at noon).

The current recommended average daily amount of vitamin D is 400 IU for children up to 1 year; 600 IU for ages 1 to 70 years (less for pregnant or breastfeeding women) and 800 IU for persons over 70, according to the National Institutes of Health. These average daily amounts, for many other reasons than just diabetes, need to be revised.
Meditation and Long-Term Benefits
This article is reserved for NCI Well Connect Members. You can get this article by signing up for NCI Well Connect here today!
Genetic Wellness Screening

Pure Genomics, our genetic wellness screening, covers 32 impeccably well-researched genes in seven categories:
  1. Methylation
  2. Vitamins and Minerals
  3. Detoxification
  4. Weight Management
  5. Cognitive Health and Memory
  6. Blood Sugar Balance
  7. Immune Health
Pure Genomics tips the balance toward optimal wellness. It only takes four simple steps to get started:
  1. Order a genetic kit from or
  2. Send your saliva sample back to 23andMe or Ancestry. They will email you when your results are ready.
  3. Download your raw genetic data file to your computer. Email us the data file.
  4. We generate your Pure Genomics report and contact you with the next step.
Email Steve for further questions or clarification.
NCI Well Connect Member Benefits
One Year Membership Is Open to Clients and Non-Clients.
Membership Includes:
  1. Free 45 Minute Pure Genomics Screening & Consultation
  2. Twice Weekly eNewsletters. Long-form issue on Monday and mid-week brief on Wednesday.
  3. Self-Help Action Plans. Access to two titles per month from our 43 title self-help Action Plan Library. Full library of titles here.
  4. Natural Foods Shopping List. Meticulously vetted, high quality food and beverages we recommend to our clients. Gluten-free, corn-free, and kosher pareve items included. Updated quarterly.
We appreciate your continued patronage and support.

Need to search for information from past issues? Type in the word(s) in the google search boxat this link.

Have a happy, healthy day,

Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Lori (not pictured)
(847) 498 3422

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