NCI Well Connect Mid-Week Brief
May 24, 2017
Dear Steve, 

DID YOU KNOW that the US Preventive Services Task Force has upheld its previous position of recommending against the use of hormone-replacement therapy (HRT), including either synthetic estrogen alone or combined with progestin, for the prevention of chronic conditions?

"The benefits of using menopausal hormone therapy to prevent chronic conditions like heart disease and diabetes do not outweigh the harms in women who have gone through menopause," said task force member Maureen G Phipps, MD, MPH, in a press statement.

ARE YOUR 23andMe RESULTS READY?
  1. Let us know if you need help emailing your genetic data.
  2. Once received, we generate your Pure Genomics report.
  3. Then, we make an appointment to go over the results.
Have a happy, healthy day. Steve and Bonnie
 
Yeast You Want No Part Of

Bonnie and Steve:
 The emerging and often drug-resistant fungus (yeast strain) Candida auris continues to spread in the United States, the Centers for Disease Control and Prevention (CDC) reported last week.

Less than a year after the first seven cases of C auris were reported in the United States, the agency now says there have been 77 patient cases, and another 45 cases have been identified via close-contact screening through May 12, 2017. Most were from healthcare facilities in three geographic areas, New York, New Jersey, and Illinois. Most patients were chronically ill.

The report, published May 19 in Morbidity and Mortality Weekly Report, reflects new data on environmental contamination and the risk for C auris transmission among close contacts.

The heightened attention to the emergence of C auris infections in healthcare facilities reflects the fact that the fungus is often multidrug resistant and has an associated mortality rate of 60%.

Screening of 390 close contacts showed that 12% were colonized by C auris. Testing of patients' rooms also recovered C auris from mattresses, beds, windowsills, chairs, infusion pumps, and countertops.

Sounds familiar? It sounds eerily similar to how the antibiotic-resistant bacteria, MRSA, started in healthcare facilities and hospitals, and then spread throughout the community.

Scarily, C Auris is considered to be a deadlier public health issue than MRSA.

Researchers say that C. Auris has arisen largely as a result of the use of fungicides on crops. The problem is even worse because unlike antibiotics, there are only a small number of anti-fungal medications.

GUT MICROBIOME
Yeast in the gut is typically kept in check by other organisms in the gut microbiota, but when that balance is thrown off by a course of antibiotics or other causes, bad yeast can get out of control and cause serious health issues. Thus, keeping a balanced gut microbiome is of the utmost importance.

Sacchromyces boulardii is a non-colonizing yeast, meaning it won't take up permanent residence in your gut, but it will stimulate your gut's production of an immune molecule that makes it difficult for "bad" yeast to stick to your gut wall. This can be taken in supplement form.

PREVENTION AND TREATMENT FOR C AURIS
If you are going to ANY healthcare facility/hospital for ANY reason, whether as a patient, visitor, or even for business, please take precautions.
  • Do not touch any surfaces with a cut or wound.
  • Do not put your hands near your mouth, eyes, ears, or nostrils.
  • Always wash your hands before you leave.
  • Before you even enter the facility, take a sacchromyces boulardii supplement. Sacchromyces boulardii is a direct competitor with C. Auris.
Medication
93% of C Auris strains were resistant to fluconazole.
54% were resistant to voriconazole.
35% were resistant to amphotericin B.
7% were resistant to echinocandins.
6% were resistant to flucytosine.

Because of the aforementioned, the agents of choice for C auris infection are echinocandins. Unfortunately, resistance of C auris to the echinocandins has also occurred.

Treatment of C auris recommended by the CDC is as follows:
Anidulafungin loading dose 200 mg IV, then 100 mg IV daily
Caspofungin loading dose 70 mg IV, then 50 mg IV daily
Micafungin 100 mg IV daily
 
What's Causing My Fingernail Issues?
This article is reserved for NCI Well Connect Members. You can get this article by signing up for NCI Well Connect!
 
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Bonnie and Steve: 
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Have a happy, healthy day,
stateofthebonnie
 

Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Jeannie
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